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What is the number one cause of skin aging?

Free radical damage. It’s a process that is triggered by sun exposure, smoke, pollution and even your own metabolism. Your skin doesn’t age, it oxidizes. Everyone knows that sun protection is your first line of defense. Based on the newest research, many skincare experts believe that antioxidants are the all important partner in a good anti-aging skincare strategy.

How effective are antioxidants?

A recent study by a group of researchers developed the first ever protocol to compare the oxidative stress protection efficacy of various topical antioxidants and rate them with Environmental Protection Factor or EPF®. The article was published in the Journal of Cosmetic Dermatology, January 2005

Measured results:

Since free radical damage is a complex process, the study used a 5-step test that measured different aspects of antioxidant capability. Each test was given a value of 20, for a total of 100 points or EPF® 100.

In this study, Idebenone, the key ingredient in PREVAGE® Anti-aging Treatments, received an Environmental Protection Factor (EPF®) of 95, higher than the other common antioxidants tested including alpha lipoic acid, kinetin, vitamin C, vitamin E or coenzyme Q10.

Sunburn Cell Assay Test:

Tests the ability of antioxidants to block sun damage (sun burn cells) to human skin from UV light.

Photochemilluminescence Test:

Measures the overall capacity to quench free radicals generated in vitro by a chemical reaction.

Primary Oxidative Products:

Free radicals attack healthy cells by breaking down the natural lipid barrier. This test measures ability to protect lipids from breaking down when exposed to oxidative stress.

Secondary Oxidative Products:

Free radicals set off a chain reaction that can be highly damaging to skin. This test shows the capacity of antioxidants to block these reactions.

UVB Irradiated Keratinocytes:

UVB rays penetrate into skin and cause damage to cells that produce collagen and elastin. This in vitro test measures the capacity of antioxidants to block these reactions in the lab.

Test Idebenone Vitamin E Kinetin CoQ10 Vitamin C Lipoic Acid
Sunburn Cell
Assay
20 16 11 6 0 5
Photochem-
illuminescence
20 20 10 15 20 5
Primary
Oxidative
Products
16 10 20 5 3 4
Secondary
Oxidative
Products
19 17 10 12 12 20
UVB – Irradiated
Keratinocytes
20 17 17 17 17 7
Total Points 95 80 68 55 52 41

Source: Pharma Cosmetix Research, LLC.

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